INFLUENZA PANDEMIC (H1N1) (22): CANADA (SASKATCHEWAN)), REASSORTMENT

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Date: Wed 3 Mar 2010
Source: Journal of Infectious Diseases 2010;201:000­000, Brief Report [edited]



Human Infection with a Triple-Reassortant Swine
Influenza A(H1N1) Virus Containing the
Hemagglutinin and Neuraminidase Genes of Seasonal Influenza Virus

Abstract:
---------
A reassortant influenza A(H1N1) virus of swine
origin distinct from the pandemic H1N1 2009
strain was isolated from 3 patients, all of whom
worked at the same large hog operation in
Saskatchewan, Canada. The genomic composition of
the isolates has not been previously reported, to
our knowledge, and was the product of a genetic
reassortment between seasonal H1N1 influenza
virus and triple-reassortant influenza virus that
emerged in North American swine during the late
1990s. The neuraminidase and hemagglutinin genes
of A/Saskatchewan/5350/2009,
A/Saskatchewan/5351/2009, and
A/Saskatchewan/5131/2009 were derived from human
H1N1 virus and were closely related to those of A/Brisbane/59/2007.

[Byline: Nathalie Bastien1; Nick A. Antonishyn3;
Ken Brandt3; Christine E. Wong3; Khami Chokani4;
Niki Vegh3; Greg B. Horsman3; Shaun Tyler1; Morag
R. Graham1,2; Frank A. Plummer1,2; Paul N. Levett3; and Yan Li12.
At: 1 National Microbiology Laboratory, Public Health Agency of Canada
2 Department of Medical Microbiology, University
of Manitoba, Winnipeg, Manitoba
3 Saskatchewan Disease Control Laboratory, Regina
4 Prince Albert Parkland Health Region, Prince Albert, Saskatchewan, Canada.]

--
Communicated by:
ProMED-mail Rapporteur Mary Marshall

[Continued surveillance should establish whether
the isolation this reassortant from the same
swine population is a unique occurrence, and more
importantly whether there has been any onward
transmission of this reassortant virus in the human population.

The province of Saskatchewan can be located in
the HealthMap/ProMED-mail interactive map of Canada at

- Mod.CP]

[see also:
Influenza pandemic (H1N1) (19): reassortment 20100302.0689
2009
----
Influenza pandemic (H1N1) 2009 (116): origin 20091126.4052
Influenza pandemic (H1N1) 2009 (04): pandemic origins 20090715.2527]
.................cp/ejp/mpp

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